The name p53 was given in 1979 describing the apparent molecular mass ; SDS-PAGE analysis indicates that it is a 53- kilodalton (kDa) protein. However, the actual mass of the full-length p53 protein (p53α) based on the sum of masses of the amino acid residues is only 43.7 kDa.
p53 es una proteína promotora de la apoptosis que actúa como sensor del estrés celular en respuesta a señales hiperproliferativas, daños en el ADN, hipoxia, acortamiento de los telómeros y otros.
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.
Mar 07, 2019 · Produces nuclear phosphoprotein involved in transcriptional regulation N terminus amino acids bind (a) TAF’s (TATA-binding protein associated factors), which attract other proteins needed to initiate gene expression, as well as (b) MDM2, which inhibits p53 and has the opposite effect as TAF’s
The p53 tumor suppressor protein
The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood.
Bookshelf ID: NBK22268
This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.
Primary information of p53 gene
p53 is a tumor suppressor protein encoded in humans by the TP53 gene. It is a crucial component in multicellular organisms, as it regulates the cell cycle and helps prevent cancer. p53 is the most frequently altered gene in human cancers.
p53 is a tumor-suppressor gene that maintains the human genetic stability and the DNA repair capability and is one of the most studied molecules in cancer research. p53 is a tumor suppressor whose levels are known to be regulated by Ub. A third mechanism for p53 stabilization may be deubiquitination by HAUSP (M. Li et al., 2002).
TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include Li-Fraumeni Syndrome and Osteogenic Sarcoma.Among its related pathways are Gastric cancer and RET signaling.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity.
The p53 Gene and Its Role in Cancer
The p53 gene (TP53) is a gene that is mutated in many cancers, and is the most common gene mutation found in cancer cells. The gene is a type of tumor suppressor gene that codes for a protein that inhibits the development and growth of tumors.
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A special issue of Human Mutation has been released: The TP53 Gene Network in the Post-Genomic Era. This special issue on TP53 propels the TP53 gene into the post-genomic era. Several fundamental features of wild-type and mutant proteins and their modifications are reviewed, as well as animal models and clinical aspects such as recommendations for patient care.
For the most systematic review on TP53 polymorphisms and their functional and clinical consequences, see Whibley et al., 2009.However, please note that this review is not up to date, in particular regarding two variants, V217M (rs35163653) and G360A (rs35993958), that are not frequent SNP based on most recent studies and thus are not considered as validated polymorphisms in the IARC database.
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional
p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damage, hypoxia and spindle damage). Activation of p53 begins through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs.MDM2 is a ubiquitin ligase that binds p53 and targets p53 for proteasomal degradation.
p53-Dependent and independent expression of p21 during cell growth, differentiation, and DNA damage Kay F. Macleod, 1 Nicole Sherry, 1 Greg Hannon, 2 David Beach, 2 Takashi Tokino, 3 Kenneth Kinzler, 3
Published in: Genes & Development · 1995Authors: Kay F Macleod · Nicole A Sherry · Gregory J Hannon · David Beach · Takashi TokinoAffiliation: Massachusetts Institute of TechnologyAbout: Cellular differentiation · Regulation of gene expression · DNA damage · Cell growth
2. The tumor suppressor gene that codes for this protein. Also called TP53. [p(rotein) 53, from its apparent molecular mass of 53 kilodaltons as extrapolated from its mobility during electrophoresis.]